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Epithelial salivary gland tumors in pediatric patients: An international collaborative study.
Quixabeira Oliveira, Gabriella Alves; Pérez-DE-Oliveira, Maria Eduarda; Robinson, Liam; Khurram, Syed Ali; Hunter, Keith; Speight, Paul M; Kowalski, Luiz Paulo; Lopes Pinto, Clóvis Antonio; Sales De Sá, Raísa; Mendonça, Elismauro Francisco; Sousa-Neto, Sebastião Silvério; de Carlucci Junior, Dorival; Mariano, Fernanda Viviane; Altemani, Albina Messias de Almeida Milani; Martins, Manoela Domingues; Zanella, Virgílio Gonzales; Perez, Danyel Elias da Cruz; Dos Santos, Jean Nunes; Romañach, Mário José; Abrahão, Aline Corrêa; Andrade, Bruno Augusto Benevenuto de; Pontes, Hélder Antônio Rebelo; Jorge Junior, Jacks; Santos-Silva, Alan Roger; Lopes, Márcio Ajudarte; Van Heerden, Willie F P; Vargas, Pablo Agustin.
Affiliation
  • Quixabeira Oliveira GA; Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil.
  • Pérez-DE-Oliveira ME; Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil.
  • Robinson L; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • Khurram SA; Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
  • Hunter K; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
  • Speight PM; Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
  • Kowalski LP; Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil; Department of Head and Neck Surgery, University of São Paulo (USP) Medical School, São Paulo, Brazil.
  • Lopes Pinto CA; Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Sales De Sá R; Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil.
  • Mendonça EF; Department of Stomatology (Oral Pathology), School of Dentistry, Federal University of Goiás (UFG), Goiânia, Brazil.
  • Sousa-Neto SS; Department of Stomatology (Oral Pathology), School of Dentistry, Federal University of Goiás (UFG), Goiânia, Brazil.
  • de Carlucci Junior D; Department of Head and Neck Surgery, University of São Paulo (USP) Medical School, São Paulo, Brazil.
  • Mariano FV; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
  • Altemani AMAM; Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
  • Martins MD; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  • Zanella VG; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Head and Neck Surgery Department, Santa Rita Hospital, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil.
  • Perez DEDC; Department of Oral Pathology, School of Dentistry, Universidade Federal de Pernambuco (UFPE), Recife, Brazil.
  • Dos Santos JN; Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia (UFBA), Salvador, Brazil.
  • Romañach MJ; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
  • Abrahão AC; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
  • Andrade BAB; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
  • Pontes HAR; Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará (UFPA), Belém, Brazil.
  • Jorge Junior J; Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil.
  • Santos-Silva AR; Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil.
  • Lopes MA; Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil.
  • Van Heerden WFP; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • Vargas PA; Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas (UNICAMP), São Paulo, Brazil; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. Electronic address: pavargas@fop.unicamp.br.
Int J Pediatr Otorhinolaryngol ; 168: 111519, 2023 May.
Article in En | MEDLINE | ID: mdl-36965251
ABSTRACT

OBJECTIVE:

Salivary gland tumors (SGT) are a diverse group of uncommon neoplasms that are rare in pediatric patients. This study aimed to characterize the clinicopathological profile of pediatric patients affected by SGT from a large case series derived from an international group of academic centers. STUDY

DESIGN:

A retrospective analysis of pediatric patients with SGT (0-19 years old) diagnosed between 2000 and 2021 from Brazil, South Africa, and the United Kingdom was performed. SPSS Statistics for Windows was used for a quantitative analysis of the data, with a descriptive analysis of the clinicopathological characteristics and the association between clinical variables and diagnoses.

RESULTS:

A total of 203 cases of epithelial SGT were included. Females were slightly more commonly (56.5%), with a mean age of 14.1 years. The palate was the most common site (43.5%), followed by the parotid gland (29%), lip (10%), and submandibular gland (7.5%). The predominant clinical presentation was a flesh-colored, smooth, and painless nodule. Pleomorphic adenoma (PA) was the most frequently diagnosed SGT (58.6%), followed by mucoepidermoid carcinoma (MEC) (26.6%). Surgery (90.8%) was the favored treatment option.

CONCLUSIONS:

Benign SGT in pediatric patients are more commonly benign than malignant tumors. Clinicians should keep PA and MEC in mind when assessing nodular lesions of possible salivary gland origin in pediatric patients.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salivary Gland Neoplasms / Carcinoma, Mucoepidermoid / Adenoma, Pleomorphic Type of study: Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Newborn Language: En Journal: Int J Pediatr Otorhinolaryngol Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salivary Gland Neoplasms / Carcinoma, Mucoepidermoid / Adenoma, Pleomorphic Type of study: Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Newborn Language: En Journal: Int J Pediatr Otorhinolaryngol Year: 2023 Document type: Article Affiliation country: