Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit.
Eng Biol
; 4(1): 10-19, 2020 Mar.
Article
in En
| MEDLINE
| ID: mdl-36970230
CAR T cell; DNA; FlpO recombinase; biochemistry; biomedical materials; cancer; cancer immunotherapy; cellular biophysics; chimeric antigen receptor T cell activity; drugs; enzymes; gene therapy; genetic engineering; increased stability; inducer drug 4OHT; inducible genetic switches; inversionexcision circuit design; mechanistic mathematical model; mechanistic modelling; molecular biophysics; optimal switch performance; statistical approximation approaches; switching response; system parameters; tumours; tyrosine recombinases; tyrosine recombinasebased DNA excision; tyrosine recombination
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Eng Biol
Year:
2020
Document type:
Article