Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit.

Bowyer, Jack E; Chakravarti, Deboki; Wong, Wilson W; Bates, Declan G

Bowyer, Jack E; Chakravarti, Deboki; Wong, Wilson W; Bates, Declan G.

Affiliation

Bowyer JE; School of Engineering University of Warwick Coventry CV4 7AL UK.
Chakravarti D; Warwick Integrative Synthetic Biology Centre Coventry CV4 7AL UK.
Wong WW; Department of Biomedical Engineering Boston University Boston MA 02215 USA.
Bates DG; Biological Design Center Boston University Boston MA 02215 USA.

Eng Biol ; 4(1): 10-19, 2020 Mar.

Article in En | MEDLINE | ID: mdl-36970230

Key words

CAR T cell; DNA; FlpO recombinase; biochemistry; biomedical materials; cancer; cancer immunotherapy; cellular biophysics; chimeric antigen receptor T cell activity; drugs; enzymes; gene therapy; genetic engineering; increased stability; inducer drug 4OHT; inducible genetic switches; inversionexcision circuit design; mechanistic mathematical model; mechanistic modelling; molecular biophysics; optimal switch performance; statistical approximation approaches; switching response; system parameters; tumours; tyrosine recombinases; tyrosine recombinasebased DNA excision; tyrosine recombination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Eng Biol Year: 2020 Document type: Article

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Eng Biol Year: 2020 Document type: Article