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Genetic and clinical factors underlying a self-reported family history of heart disease.
Jowell, Amanda R; Bhattacharya, Romit; Marnell, Christopher; Wong, Megan; Haidermota, Sara; Trinder, Mark; Fahed, Akl C; Peloso, Gina M; Honigberg, Michael C; Natarajan, Pradeep.
Affiliation
  • Jowell AR; Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
  • Bhattacharya R; Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
  • Marnell C; Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street Suite 320, Boston, MA 02114, USA.
  • Wong M; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Merkin Building, 415 Main Street, Cambridge, MA 02142, USA.
  • Haidermota S; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Trinder M; Division of Cardiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
  • Fahed AC; Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street Suite 320, Boston, MA 02114, USA.
  • Peloso GM; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Merkin Building, 415 Main Street, Cambridge, MA 02142, USA.
  • Honigberg MC; Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street Suite 320, Boston, MA 02114, USA.
  • Natarajan P; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Merkin Building, 415 Main Street, Cambridge, MA 02142, USA.
Eur J Prev Cardiol ; 30(15): 1571-1579, 2023 10 26.
Article in En | MEDLINE | ID: mdl-37011137
With advances in genetics, it is tempting to assume that the 'family history' of a patient is an imperfect proxy for information we can already glean from genetics and laboratory tests. However, this study shows that much of the information contained in the self-reported family history of heart disease is not captured by currently available genetic and clinical biomarkers and highlights an important knowledge gap. Clinically used biomarkers explained only 21.9% of the likelihood of a patient reporting a family history of heart disease, while genetics explained 22.2%, and a combined model explained 36% of this likelihoodThe majority of the risk of reporting a family history went unexplained, implying that family history still has major relevance in clinical practice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coronary Artery Disease / Hypertension Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Eur J Prev Cardiol Year: 2023 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coronary Artery Disease / Hypertension Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Eur J Prev Cardiol Year: 2023 Document type: Article Affiliation country: Country of publication: