Guided Isolation of New Cytotoxic Cassane Diterpenoids from Caesalpinia sappan.
Chem Biodivers
; 20(5): e202300211, 2023 May.
Article
in En
| MEDLINE
| ID: mdl-37014182
ABSTRACT
Guided by an MS/MS-based molecular networking, six undescribed cassane diterpenoids and three known ones were isolated and identified from the seeds of Caesalpinia sappan. Their structures were unequivocally elucidated by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Cytotoxic evaluation showed that phanginin JA exhibited significant antiproliferative activities against human non-small cell lung cancer (A549) cells with IC50 values of 16.79±0.83â
µM. Further flow cytometry analysis revealed that phanginin JA could exert apoptotic effect of A549â
cells by arresting cell cycle in G0/G1 phase.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Non-Small-Cell Lung
/
Caesalpinia
/
Diterpenes
/
Lung Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Chem Biodivers
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2023
Document type:
Article