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Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines.
Gupta, Anish; Jandial, Tanvi; Karuppasamy, Muthu; Bhuvanesh, Nattamai; Nagarajan, Subbiah; Maheswari, C Uma; Sridharan, Vellaisamy.
Affiliation
  • Gupta A; Department of Chemistry and Chemical Sciences, Central University of Jammu, Rahya-Suchani (Bagla), District-Samba, Jammu, 181143, JK, India. vesridharan@gmail.com.
  • Jandial T; Department of Chemistry and Chemical Sciences, Central University of Jammu, Rahya-Suchani (Bagla), District-Samba, Jammu, 181143, JK, India. vesridharan@gmail.com.
  • Karuppasamy M; Department of Chemistry and Chemical Sciences, Central University of Jammu, Rahya-Suchani (Bagla), District-Samba, Jammu, 181143, JK, India. vesridharan@gmail.com.
  • Bhuvanesh N; Department of Chemistry, Texas A & M University, College Station, Texas, 77843, USA.
  • Nagarajan S; Department of Chemistry, National Institute of Technology, Warangal, Warangal, 506004, Telangana, India.
  • Maheswari CU; Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, 613401, Tamil Nadu, India.
  • Sridharan V; Department of Chemistry and Chemical Sciences, Central University of Jammu, Rahya-Suchani (Bagla), District-Samba, Jammu, 181143, JK, India. vesridharan@gmail.com.
Chem Commun (Camb) ; 59(35): 5233-5236, 2023 Apr 27.
Article in En | MEDLINE | ID: mdl-37040145
ABSTRACT
Palladium-catalyzed, solvent-dependent intramolecular oxypalladation-triggered domino sequences of internal alkynes bearing tethered nucleophilic carboxylic ester and electrophilic enone functionalities were developed for the chemodivergent synthesis of two completely distinct biologically significant complex molecules including isochromenone-fused benzazepines and isobenzofuranone-fused tetrahydroquinolines/chromanes in a single synthetic operation.

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: