Long-term adverse neurodevelopmental outcomes of discordant twins delivered at term: A nationwide population-based study.
BJOG
; 130(11): 1370-1378, 2023 10.
Article
in En
| MEDLINE
| ID: mdl-37077036
ABSTRACT
OBJECTIVE:
To evaluate long-term adverse neurodevelopmental outcomes of discordant twins delivered at term.DESIGN:
Retrospective cohort study.SETTING:
Nationwide (Republic of Korea). POPULATION All twin children delivered at term between 2007 and 2010.METHODS:
The study population was divided into two groups according to inter-twin birthweight discordancy the 'concordant twin group', twin pairs with inter-twin birthweight discordancy less than 20%; and the 'discordant twin group', twin pairs with inter-twin birthweight discordancy of 20% or more. The risk of long-term adverse neurodevelopmental outcomes was compared between the concordant twin group and the discordant twin group. Long-term adverse neurodevelopmental outcomes between smaller and larger twin children within twin pairs were further analysed. The composite adverse neurodevelopmental outcome was defined as the presence of at least one of the following motor developmental delay, cognitive developmental delay, autism spectrum disorders/attention deficit hyperactivity disorders, tics/stereotypical behaviour or epileptic/febrile seizure. MAIN OUTCOMEMEASURES:
Long-term adverse neurodevelopmental outcome.RESULTS:
Of 22 468 twin children (11 234 pairs) included, 3412 (15.19%) twin children were discordant. The risk of composite adverse neurodevelopmental outcome was higher in the discordant twin group than in the concordant twin group (adjusted hazard ratio [HR] 1.13, 95% CI 1.03-1.24). The long-term adverse neurodevelopmental outcomes were not significantly different between smaller and larger twin children in discordant twin pairs (adjusted HR 1.01, 95% CI 0.81-1.28).CONCLUSION:
In twin pairs delivered at term, an inter-twin birthweight discordancy of 20% or greater was associated with long-term adverse neurodevelopmental outcomes; and long-term adverse neurodevelopmental outcomes were not significantly different in smaller or larger twin children in discordant twin pairs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications
/
Infant, Newborn, Diseases
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Child
/
Female
/
Humans
/
Newborn
Language:
En
Journal:
BJOG
Journal subject:
GINECOLOGIA
/
OBSTETRICIA
Year:
2023
Document type:
Article