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Simultaneous targeting of PD-1 and IL-2Rßγ with radiation therapy inhibits pancreatic cancer growth and metastasis.
Piper, Miles; Hoen, Maureen; Darragh, Laurel B; Knitz, Michael W; Nguyen, Diemmy; Gadwa, Jacob; Durini, Greta; Karakoc, Idil; Grier, Abby; Neupert, Brooke; Van Court, Benjamin; Abdelazeem, Khalid N M; Yu, Justin; Olimpo, Nicholas A; Corbo, Sophia; Ross, Richard Blake; Pham, Tiffany T; Joshi, Molishree; Kedl, Ross M; Saviola, Anthony J; Amann, Maria; Umaña, Pablo; Codarri Deak, Laura; Klein, Christian; D'Alessandro, Angelo; Karam, Sana D.
Affiliation
  • Piper M; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Hoen M; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Darragh LB; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Microbiology and Immunology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Knitz MW; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Nguyen D; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Gadwa J; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Durini G; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland.
  • Karakoc I; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland.
  • Grier A; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Neupert B; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Van Court B; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Abdelazeem KNM; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Yu J; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Olimpo NA; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Corbo S; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Ross RB; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Pham TT; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Joshi M; Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Kedl RM; Department of Microbiology and Immunology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Saviola AJ; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Amann M; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland.
  • Umaña P; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland.
  • Codarri Deak L; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland.
  • Klein C; Roche Innovation Center Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland.
  • D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Karam SD; Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Microbiology and Immunology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: sana.karam@cuanschutz.edu.
Cancer Cell ; 41(5): 950-969.e6, 2023 05 08.
Article in En | MEDLINE | ID: mdl-37116489
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Carcinoma, Pancreatic Ductal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Carcinoma, Pancreatic Ductal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2023 Document type: Article Affiliation country: