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S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.
Ko, Yeonjin; Hong, Mannkyu; Lee, Seungbeom; Kumar, Manoj; Ibrahim, Lara; Nutsch, Kayla; Stanton, Caroline; Sondermann, Phillip; Sandoval, Braddock; Bulos, Maya L; Iaconelli, Jonathan; Chatterjee, Arnab K; Wiseman, R Luke; Schultz, Peter G; Bollong, Michael J.
Affiliation
  • Ko Y; Department of Chemistry, The Scripps Research Institute, San Diego, CA 92037.
  • Hong M; Department of Chemistry, The Scripps Research Institute, San Diego, CA 92037.
  • Lee S; Department of Chemistry, The Scripps Research Institute, San Diego, CA 92037.
  • Kumar M; Calibr, A Division of Scripps Research, San Diego, CA 92037.
  • Ibrahim L; Department of Chemistry, The Scripps Research Institute, San Diego, CA 92037.
  • Nutsch K; Department of Molecular Medicine, The Scripps Research Institute, San Diego, CA 92037.
  • Stanton C; Department of Chemistry, The Scripps Research Institute, San Diego, CA 92037.
  • Sondermann P; Department of Chemistry, The Scripps Research Institute, San Diego, CA 92037.
  • Sandoval B; Department of Molecular Medicine, The Scripps Research Institute, San Diego, CA 92037.
  • Bulos ML; Department of Chemistry, The Scripps Research Institute, San Diego, CA 92037.
  • Iaconelli J; Department of Chemistry, The Scripps Research Institute, San Diego, CA 92037.
  • Chatterjee AK; Department of Chemistry, The Scripps Research Institute, San Diego, CA 92037.
  • Wiseman RL; Department of Chemistry, The Scripps Research Institute, San Diego, CA 92037.
  • Schultz PG; Calibr, A Division of Scripps Research, San Diego, CA 92037.
  • Bollong MJ; Department of Molecular Medicine, The Scripps Research Institute, San Diego, CA 92037.
Proc Natl Acad Sci U S A ; 120(20): e2300763120, 2023 05 16.
Article in En | MEDLINE | ID: mdl-37155889
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine / NF-E2-Related Factor 2 Type of study: Prognostic_studies Language: En Journal: Proc Natl Acad Sci U S A Year: 2023 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine / NF-E2-Related Factor 2 Type of study: Prognostic_studies Language: En Journal: Proc Natl Acad Sci U S A Year: 2023 Document type: Article Country of publication: