Your browser doesn't support javascript.
loading
Differences Among Native Hawaiian, Asian, and White Patients with Progressive Supranuclear Palsy.
Kannan, Ashok; Ishikawa, Kyle; Chen, John; Krening, Emma; Gao, Fay; Ross, G Webster; Bruno, Michiko Kimura.
Affiliation
  • Kannan A; John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, Hawaii, USA.
  • Ishikawa K; John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, Hawaii, USA.
  • Chen J; John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, Hawaii, USA.
  • Krening E; The Queen's Medical Center, Honolulu, Hawaii, USA.
  • Gao F; John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, Hawaii, USA.
  • Ross GW; The Queen's Medical Center, Honolulu, Hawaii, USA.
  • Bruno MK; Pacific Health Research and Education Institute, Virginia Pacific Islands Health Care System, Honolulu, Hawaii, United States.
Mov Disord ; 38(7): 1355-1361, 2023 07.
Article in En | MEDLINE | ID: mdl-37157060
BACKGROUND: Most studies of progressive supranuclear palsy (PSP) have been conducted in White populations. OBJECTIVE: The objective of this study was to identify whether differences exist for patients with PSP among Whites, East Asians (EAs), and Native Hawaiians/Pacific Islanders (NHPIs) in Hawaii. METHODS: We conducted a single-center, retrospective study of patients meeting Movement Disorder Society probable PSP criteria (2006-2021). Data variables included age of onset and diagnosis, comorbidities, and survival rate. Variables were compared across groups using Fisher's exact test, Kruskal-Wallis rank sum test, and log-rank tests. RESULTS: A total of 94 (59 EAs, 9 NHPIs, 16 Whites, and 10 Others) patients were identified. Mean age ± standard deviation (in years) of symptom onset/diagnosis were both youngest in NHPIs (64.0 ± 7.2/66.3 ± 8.0) followed by Whites (70.8 ± 7.6/73.9 ± 7.8), then EAs (75.9 ± 8.2/79.2 ± 8.3) (P < 0.001). Median survival from diagnosis was significantly lower (P < 0.05) in NHPIs (2 years) compared with EAs (4 years) and Whites (6 years). CONCLUSIONS: There may be racial disparities for PSP, and studies are needed to identify genetic, environmental, and socioeconomic contributions. © 2023 International Parkinson and Movement Disorder Society.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Supranuclear Palsy, Progressive / Movement Disorders Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Humans / Middle aged Country/Region as subject: America do norte Language: En Journal: Mov Disord Journal subject: NEUROLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Supranuclear Palsy, Progressive / Movement Disorders Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Humans / Middle aged Country/Region as subject: America do norte Language: En Journal: Mov Disord Journal subject: NEUROLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication: