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Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity.
Leonard, Elissa K; Tomala, Jakub; Gould, Joseph R; Leff, Michael I; Lin, Jian-Xin; Li, Peng; Porter, Mitchell J; Johansen, Eric R; Thompson, Ladaisha; Cao, Shanelle D; Henclova, Tereza; Huliciak, Maros; Vanek, Ondrej; Kovar, Marek; Leonard, Warren J; Spangler, Jamie B.
Affiliation
  • Leonard EK; Department of Biomedical Engineering, Johns Hopkins University School of Medicine; Baltimore, USA.
  • Tomala J; Institute of Biotechnology of the Academy of Sciences of the Czech Republic; Vestec, Czech Republic.
  • Gould JR; Department of Biomedical Engineering, Johns Hopkins University School of Medicine; Baltimore, USA.
  • Leff MI; Department of Biology, Johns Hopkins University; Baltimore, USA.
  • Lin JX; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda, USA.
  • Li P; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda, USA.
  • Porter MJ; Department of Chemistry, Johns Hopkins University; Baltimore, USA.
  • Johansen ER; Department of Chemistry, Johns Hopkins University; Baltimore, USA.
  • Thompson L; Department of Biomedical Engineering, Johns Hopkins University School of Medicine; Baltimore, USA.
  • Cao SD; Department of Chemical & Biomolecular Engineering, Johns Hopkins University School of Engineering; Baltimore, USA.
  • Henclova T; Institute of Biotechnology of the Academy of Sciences of the Czech Republic; Vestec, Czech Republic.
  • Huliciak M; Institute of Biotechnology of the Academy of Sciences of the Czech Republic; Vestec, Czech Republic.
  • Vanek O; Department of Biochemistry, Faculty of Science, Charles University; Prague, Czech Republic.
  • Kovar M; Laboratory of Tumor Immunology, Institute of Microbiology of the Academy of Sciences of the Czech Republic; Prague, Czech Republic.
  • Leonard WJ; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda, USA.
  • Spangler JB; Department of Biomedical Engineering, Johns Hopkins University School of Medicine; Baltimore, USA.
bioRxiv ; 2023 May 04.
Article in En | MEDLINE | ID: mdl-37205604

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2023 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2023 Document type: Article Affiliation country: