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Discovery of thiohydantoin based antagonists of androgen receptor with efficient degradation for the treatment of prostate cancer.
Chang, Xiujin; Zhang, Di; Qu, Fangui; Xie, Youquan; Chen, Tian; Zhang, Yuqing; Du, Qianming; Bian, Jinlei; Li, Zhiyu; Wang, Jubo; Xu, Xi.
Affiliation
  • Chang X; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China.
  • Zhang D; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China.
  • Qu F; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China.
  • Xie Y; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China.
  • Chen T; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China.
  • Zhang Y; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China.
  • Du Q; General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, PR China.
  • Bian J; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China.
  • Li Z; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China.
  • Wang J; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: 1620194588@cpu.edu.cn.
  • Xu X; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: xuxi@cpu.edu.cn.
Eur J Med Chem ; 257: 115490, 2023 Sep 05.
Article in En | MEDLINE | ID: mdl-37209451
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Receptors, Androgen Limits: Humans / Male Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Receptors, Androgen Limits: Humans / Male Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article Country of publication: