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Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy.
Shibutani, Toshihiro; Goto, Risa; Miyazaki, Isao; Hashimoto, Akihiro; Suzuki, Takamasa; Ishida, Keiji; Haruma, Tomonori; Osada, Toshihiro; Harada, Takafumi; Fujita, Hidenori; Ohkubo, Shuichi.
Affiliation
  • Shibutani T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan. t-shibutani@taiho.co.jp.
  • Goto R; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
  • Miyazaki I; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
  • Hashimoto A; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
  • Suzuki T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
  • Ishida K; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
  • Haruma T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
  • Osada T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
  • Harada T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
  • Fujita H; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
  • Ohkubo S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Sci Rep ; 13(1): 8821, 2023 05 31.
Article in En | MEDLINE | ID: mdl-37258621
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Neoplasms Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Rep Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Neoplasms Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Rep Year: 2023 Document type: Article Affiliation country: Country of publication: