Amino acids and the changing face of the α-cell.
Peptides
; 166: 171039, 2023 Aug.
Article
in En
| MEDLINE
| ID: mdl-37295651
ABSTRACT
Glucagon has long been defined by its glucogenic action and as a result α-cells have been characterised based largely on their interaction with glucose. Recent findings have challenged this preconception, bringing to the fore the significant role glucagon plays in amino acid breakdown and underlining the importance of amino acids in glucagon secretion. The challenge that remains is defining the mechanism that underlie these effects - understanding which amino acids are most important, how they act on the α-cell and how their actions integrate with other fuels such as glucose and fatty acids. This review will describe the current relationship between amino acids and glucagon and how we can use this knowledge to redefine the α-cell.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glucagon-Secreting Cells
/
Amino Acids
Language:
En
Journal:
Peptides
Year:
2023
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA