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Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases.
Zorn, Katja; Back, Catherine R; Barringer, Rob; Chadimová, Veronika; Manzo-Ruiz, Monserrat; Mbatha, Sbusisiwe Z; Mobarec, Juan-Carlos; Williams, Sam E; van der Kamp, Marc W; Race, Paul R; Willis, Christine L; Hayes, Martin A.
Affiliation
  • Zorn K; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden.
  • Back CR; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
  • Barringer R; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
  • Chadimová V; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden.
  • Manzo-Ruiz M; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
  • Mbatha SZ; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.
  • Mobarec JC; Mechanistic and Structural Biology, Biopharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK.
  • Williams SE; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
  • van der Kamp MW; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
  • Race PR; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.
  • Willis CL; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.
  • Hayes MA; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden.
Chembiochem ; 24(14): e202300382, 2023 07 17.
Article in En | MEDLINE | ID: mdl-37305956
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbon / Proteins Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbon / Proteins Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2023 Document type: Article Affiliation country: