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Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein.
Sacerdoti, Mariana; Gross, Lissy Z F; Riley, Andrew M; Zehnder, Karin; Ghode, Abhijeet; Klinke, Sebastián; Anand, Ganesh Srinivasan; Paris, Kristina; Winkel, Angelika; Herbrand, Amanda K; Godage, H Yasmin; Cozier, Gyles E; Süß, Evelyn; Schulze, Jörg O; Pastor-Flores, Daniel; Bollini, Mariela; Cappellari, María Victoria; Svergun, Dmitri; Gräwert, Melissa A; Aramendia, Pedro F; Leroux, Alejandro E; Potter, Barry V L; Camacho, Carlos J; Biondi, Ricardo M.
Affiliation
  • Sacerdoti M; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires C1425FQD, Argentina.
  • Gross LZF; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires C1425FQD, Argentina.
  • Riley AM; Medicinal Chemistry and Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
  • Zehnder K; Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Ghode A; Biological Sciences, National University of Singapore, Singapore 119077, Singapore.
  • Klinke S; Fundación Instituto Leloir, IIBBA-CONICET, and Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires C1405BWE, Argentina.
  • Anand GS; Biological Sciences, National University of Singapore, Singapore 119077, Singapore.
  • Paris K; Department of Chemistry, Huck Institutes of the Life Sciences, Pennsylvania State University, 104 Chemistry Building, University Park, PA 16802, USA.
  • Winkel A; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Herbrand AK; Department of Statistics, University of Pittsburgh, WWPH 1821, Pittsburgh, PA 15213, USA.
  • Godage HY; Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Cozier GE; Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Süß E; Wolfson Laboratory of Medicinal Chemistry, Department of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AY, UK.
  • Schulze JO; Wolfson Laboratory of Medicinal Chemistry, Department of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AY, UK.
  • Pastor-Flores D; Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Bollini M; Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Cappellari MV; Department of Internal Medicine I, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
  • Svergun D; KBI Biopharma, Technologielaan 8, B-3001 Leuven, Belgium.
  • Gräwert MA; Centro de Investigaciones en Bionanociencias 'Elizabeth Jares-Erijman' CIBION, CONICET, Buenos Aires C1425FQD, Argentina.
  • Aramendia PF; Centro de Investigaciones en Bionanociencias 'Elizabeth Jares-Erijman' CIBION, CONICET, Buenos Aires C1425FQD, Argentina.
  • Leroux AE; European Molecular Biology Laboratory (EMBL), Hamburg Unit, 22607 Hamburg, Germany.
  • Potter BVL; European Molecular Biology Laboratory (EMBL), Hamburg Unit, 22607 Hamburg, Germany.
  • Camacho CJ; Centro de Investigaciones en Bionanociencias 'Elizabeth Jares-Erijman' CIBION, CONICET, Buenos Aires C1425FQD, Argentina.
  • Biondi RM; Departamento de Química Inorgánica, Analítica y Química Física, FCEN, Universidad de Buenos Aires, Buenos Aires C1428EHA, Argentina.
Sci Signal ; 16(789): eadd3184, 2023 06 13.
Article in En | MEDLINE | ID: mdl-37311034
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyphosphates / Mammals Limits: Animals Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2023 Document type: Article Affiliation country:
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyphosphates / Mammals Limits: Animals Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2023 Document type: Article Affiliation country: