Blending Low-Frequency Vibrations and Push-Pull Effects Affords Superior Photoacoustic Imaging Agents.
Angew Chem Int Ed Engl
; 62(32): e202307797, 2023 08 07.
Article
in En
| MEDLINE
| ID: mdl-37336786
ABSTRACT
Photoacoustic imaging (PAI), a state-of-the-art noninvasive in vivo imaging technique, has been widely used in clinical disease diagnosis. However, the design of high-performance PAI agents with three key characteristics, i.e., near-infrared (NIR) absorption (λabs >800â
nm), intense PA signals, and excellent photostability, remains a challenging goal. Herein, we present a facile but effective approach for engineering PAI agents by amplifying intramolecular low-frequency vibrations and enhancing the push-pull effect. As a demonstration of this blended approach, we constructed a PAI agent (BDP1-NEt2 ) based on the boron-dipyrromethene (BODIPY) scaffold. Compared with indocyanine green (ICG, an FDA-approved organic dye widely utilized in PAI studies; λabs =788â
nm), BDP1-NEt2 exhibited a UV/Vis-NIR spectrum peaked at 825â
nm, superior in vivo PA signal intensity and outstanding stability to offer improved tumor diagnostics. We believe this work provides a promising strategy to develop the next generation of PAI agents.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Photoacoustic Techniques
Type of study:
Diagnostic_studies
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2023
Document type:
Article