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Tipifarnib Potentiates the Antitumor Effects of PI3Kα Inhibition in PIK3CA- and HRAS-Dysregulated HNSCC via Convergent Inhibition of mTOR Activity.
Smith, Alison E; Chan, Stacia; Wang, Zhiyong; McCloskey, Asako; Reilly, Quinn; Wang, Jayden Z; Patel, Hetika Vora; Koshizuka, Keiichi; Soifer, Harris S; Kessler, Linda; Dayoub, Ashley; Villaflor, Victoria; Adkins, Douglas R; Bruce, Justine Y; Ho, Alan L; Perez, Cesar A; Hanna, Glenn J; Gascó Hernández, Amaya; Saunders, Andrew; Dale, Stephen; Gutkind, J Silvio; Burrows, Francis; Malik, Shivani.
Affiliation
  • Smith AE; Kura Oncology, Inc., San Diego, California.
  • Chan S; Kura Oncology, Inc., San Diego, California.
  • Wang Z; Moores Cancer Center, University of California San Diego, La Jolla, California.
  • McCloskey A; Kura Oncology, Inc., San Diego, California.
  • Reilly Q; Kura Oncology, Inc., San Diego, California.
  • Wang JZ; Kura Oncology, Inc., San Diego, California.
  • Patel HV; Kura Oncology, Inc., San Diego, California.
  • Koshizuka K; Moores Cancer Center, University of California San Diego, La Jolla, California.
  • Soifer HS; Kura Oncology, Inc., San Diego, California.
  • Kessler L; Kura Oncology, Inc., San Diego, California.
  • Dayoub A; Kura Oncology, Inc., Boston, Massachusetts.
  • Villaflor V; City of Hope Comprehensive Cancer Center, Duarte, California.
  • Adkins DR; Washington University at St. Louis, St. Louis, Missouri.
  • Bruce JY; Wisconsin University, Madison, Wisconsin.
  • Ho AL; Memorial Sloan Kettering Cancer Center, New York, New York.
  • Perez CA; Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando, Florida.
  • Hanna GJ; Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Gascó Hernández A; Kura Oncology, Inc., Boston, Massachusetts.
  • Saunders A; Kura Oncology, Inc., Boston, Massachusetts.
  • Dale S; Kura Oncology, Inc., Boston, Massachusetts.
  • Gutkind JS; Moores Cancer Center, University of California San Diego, La Jolla, California.
  • Burrows F; Department of Pharmacology, University of California San Diego, La Jolla, California.
  • Malik S; Kura Oncology, Inc., San Diego, California.
Cancer Res ; 83(19): 3252-3263, 2023 10 02.
Article in En | MEDLINE | ID: mdl-37339176
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Head and Neck Neoplasms Limits: Humans Language: En Journal: Cancer Res Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Head and Neck Neoplasms Limits: Humans Language: En Journal: Cancer Res Year: 2023 Document type: Article