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Preventing occludin tight-junction disruption via inhibition of microRNA-193b-5p attenuates viral load and influenza-induced lung injury.
Vaswani, Chirag M; Varkouhi, Amir K; Gupta, Sahil; Ektesabi, Amin M; Tsoporis, James N; Yousef, Sadiya; Plant, Pamela J; da Silva, Adriana L; Cen, Yuchen; Tseng, Yi-Chieh; Batah, Sabrina S; Fabro, Alexandre T; Advani, Suzanne L; Advani, Andrew; Leong-Poi, Howard; Marshall, John C; Garcia, Cristiana C; Rocco, Patricia R M; Albaiceta, Guillermo M; Sebastian-Bolz, Steffen; Watts, Tania H; Moraes, Theo J; Capelozzi, Vera L; Dos Santos, Claudia C.
Affiliation
  • Vaswani CM; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
  • Varkouhi AK; Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ, USA.
  • Gupta S; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Faculty of Medicine, School of Medicine, The University of Queensland, Herston, QLD 4006, Australia.
  • Ektesabi AM; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Tsoporis JN; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
  • Yousef S; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
  • Plant PJ; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
  • da Silva AL; Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; COVID-19 Virus Network from Ministry of Science, Technology, and Innovation, Brazilian Council for Scientific and Technological Development, and Foundatio
  • Cen Y; Program in Translational Medicine, SickKids Research Institute, Toronto, ON, Canada.
  • Tseng YC; Program in Translational Medicine, SickKids Research Institute, Toronto, ON, Canada.
  • Batah SS; Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
  • Fabro AT; Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
  • Advani SL; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
  • Advani A; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
  • Leong-Poi H; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Marshall JC; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Garcia CC; Laboratory of Respiratory, Exanthematic Viruses, Enterovirus and Viral Emergencies, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil; Integrated Research Group on Biomarkers. René Rachou Institute, FIOCRUZ Minas, Belo Horizonte, Brazil.
  • Rocco PRM; Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; COVID-19 Virus Network from Ministry of Science, Technology, and Innovation, Brazilian Council for Scientific and Technological Development, and Foundatio
  • Albaiceta GM; Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain; Unidad de Cuidados Intensivos Cardiológicos, Hospital Universitario Central de Asturias, Oviedo, Spain; CIBER-Enfermedades Respiratorias, Instituto de Salud Carl
  • Sebastian-Bolz S; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Watts TH; Department of Immunology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Moraes TJ; Program in Translational Medicine, SickKids Research Institute, Toronto, ON, Canada; Department of Pediatrics University of Toronto and Respirology, Hospital for Sick Children, Toronto, ON, Canada.
  • Capelozzi VL; Department of Pathology, University of São Paulo, São Paulo, Brazil.
  • Dos Santos CC; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Laboratory Me
Mol Ther ; 31(9): 2681-2701, 2023 09 06.
Article in En | MEDLINE | ID: mdl-37340634
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MicroRNAs / Influenza, Human / Influenza A Virus, H1N1 Subtype / Lung Injury Limits: Animals / Humans Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MicroRNAs / Influenza, Human / Influenza A Virus, H1N1 Subtype / Lung Injury Limits: Animals / Humans Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2023 Document type: Article Affiliation country: Country of publication: