Aldose reductase and glutathione in senile cataract nucleus of diabetics and non-diabetics.
Int Ophthalmol
; 43(10): 3673-3680, 2023 Oct.
Article
in En
| MEDLINE
| ID: mdl-37395905
ABSTRACT
PURPOSE:
The aim is to evaluate the aldose reductase (AR) and glutathione (GSH) activity in the nucleus of senile cataract in type 2 diabetes and non-diabetic group of patients.METHODS:
A total of 62 patients including 31 diabetics and 31 non- diabetics who were undergoing cataract surgery were included. Nucleus extracted was sent for analysis of AR and GSH activity while blood sample was taken for glycated haemoglobin (HbA1c) levels. STATISTICALANALYSIS:
Data were analysed using IBM SPSS 25. Comparison was carried out by unpaired T-test and correlations were established by Pearson's correlation. The p value less than 0.05 was considered significant for all analyses. STUDYDESIGN:
This is a prospective cross-sectional comparative study.RESULTS:
In this study, diabetic group patients showed earlier progression of cataract as compared to the non-diabetic group (p-value 0.0310). Mean HbA1c in the diabetic group was 7.34% compared to the non-diabetic group of 5.7% (p value < 0.001). AR in the diabetic patients was 2.07 mU/mg while the non-diabetic group was 0.22 mU/mg (p-value < 0.001). GSH in the diabetic group was 3.38 µMol/g and the non-diabetic group was 7.47 µMol/g (p value < 0.001). HbA1c showed positive correlation with AR among the diabetic group (p-value 0.028).CONCLUSION:
Elevated oxidative stress can be strongly attributed to high AR and low GSH activity among the diabetic group as compared to the non-diabetic group and can lead to early cataract formation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cataract
/
Diabetes Mellitus, Type 2
/
Lens, Crystalline
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Int Ophthalmol
Year:
2023
Document type:
Article
Affiliation country: