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Sexual dimorphism in the murine model of extraparenchymal neurocysticercosis.
Moreira, Carlos Alexandre Aguiar; Murayama, Luis Henrique Vallesquino; Martins, Tatiane de Camargo; Oliveira, Vinicius Tadeu; Generoso, Diego; Machado, Vania Maria de Vasconcelos; Batah, Sabrina Setembre; Fabro, Alexandre Todorovic; Bazan, Rodrigo; Zanini, Marco Antônio; Sciutto, Edda; Fleury, Agnès; Hamamoto Filho, Pedro Tadao.
Affiliation
  • Moreira CAA; Department of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
  • Murayama LHV; Department of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
  • Martins TC; Department of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
  • Oliveira VT; Department of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
  • Generoso D; Department of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
  • Machado VMV; School of Veterinary Medicine and Animal Sciences, UNESP - São Paulo State University, Botucatu, Brazil.
  • Batah SS; Ribeirão Preto Medical School, USP - São Paulo University, Ribeirão Preto, Brazil.
  • Fabro AT; Ribeirão Preto Medical School, USP - São Paulo University, Ribeirão Preto, Brazil.
  • Bazan R; Department of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
  • Zanini MA; Department of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
  • Sciutto E; Institute of Biomedical Investigations, UNAM - National Autonomous University of Mexico, Mexico City, Mexico.
  • Fleury A; Institute of Biomedical Investigations, UNAM - National Autonomous University of Mexico, Mexico City, Mexico.
  • Hamamoto Filho PT; Instituto Nacional de Neurología y Neurocirurgía, Mexico City, Mexico.
Parasitol Res ; 122(9): 2147-2154, 2023 Sep.
Article in En | MEDLINE | ID: mdl-37428312
ABSTRACT
Neurocysticercosis is a heterogeneous disease, and the patient's sex seems to play a role in this heterogeneity. Hosts' sexual dimorphism in cysticercosis has been largely explored in the murine model of intraperitoneal Taenia crassiceps cysticercosis. In this study, we investigated the sexual dimorphism of inflammatory responses in a rat model of extraparenchymal neurocysticercosis caused by T. crassiceps. T. crassiceps cysticerci were inoculated in the subarachnoid space of Wistar rats (25 females, 22 males). Ninety days later, the rats were euthanized for histologic, immunohistochemistry, and cytokines studies. Ten animals also underwent a 7-T magnetic resonance imaging (MRI). Female rats presented a higher concentration of immune cells in the arachnoid-brain interface, reactive astrogliosis in the periventricular region, in situ pro-inflammatory cytokine (interleukin [IL]-6) and anti-inflammatory cytokine (IL-10), and more intense hydrocephalus on MRI than males. Intracranial hypertension signals were not observed during the observational period. Overall, these results suggest sexual dimorphism in the intracranial inflammatory response that accompanied T. crassiceps extraparenchymal neurocysticercosis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Taenia / Cysticercosis / Neurocysticercosis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Parasitol Res Journal subject: PARASITOLOGIA Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Taenia / Cysticercosis / Neurocysticercosis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Parasitol Res Journal subject: PARASITOLOGIA Year: 2023 Document type: Article Affiliation country: