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Combined PD-L1/TGFß blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.
Castiglioni, Alessandra; Yang, Yagai; Williams, Katherine; Gogineni, Alvin; Lane, Ryan S; Wang, Amber W; Shyer, Justin A; Zhang, Zhe; Mittman, Stephanie; Gutierrez, Alan; Astarita, Jillian L; Thai, Minh; Hung, Jeffrey; Yang, Yeqing Angela; Pourmohamad, Tony; Himmels, Patricia; De Simone, Marco; Elstrott, Justin; Capietto, Aude-Hélène; Cubas, Rafael; Modrusan, Zora; Sandoval, Wendy; Ziai, James; Gould, Stephen E; Fu, Wenxian; Wang, Yulei; Koerber, James T; Sanjabi, Shomyseh; Mellman, Ira; Turley, Shannon J; Müller, Sören.
Affiliation
  • Castiglioni A; Genentech, South San Francisco, CA, USA.
  • Yang Y; Genentech, South San Francisco, CA, USA.
  • Williams K; Genentech, South San Francisco, CA, USA.
  • Gogineni A; Genentech, South San Francisco, CA, USA.
  • Lane RS; Genentech, South San Francisco, CA, USA.
  • Wang AW; Genentech, South San Francisco, CA, USA.
  • Shyer JA; Genentech, South San Francisco, CA, USA.
  • Zhang Z; Genentech, South San Francisco, CA, USA.
  • Mittman S; Genentech, South San Francisco, CA, USA.
  • Gutierrez A; Genentech, South San Francisco, CA, USA.
  • Astarita JL; Genentech, South San Francisco, CA, USA.
  • Thai M; Genentech, South San Francisco, CA, USA.
  • Hung J; Genentech, South San Francisco, CA, USA.
  • Yang YA; Genentech, South San Francisco, CA, USA.
  • Pourmohamad T; Genentech, South San Francisco, CA, USA.
  • Himmels P; Genentech, South San Francisco, CA, USA.
  • De Simone M; Genentech, South San Francisco, CA, USA.
  • Elstrott J; Genentech, South San Francisco, CA, USA.
  • Capietto AH; Genentech, South San Francisco, CA, USA.
  • Cubas R; Genentech, South San Francisco, CA, USA.
  • Modrusan Z; Genentech, South San Francisco, CA, USA.
  • Sandoval W; Genentech, South San Francisco, CA, USA.
  • Ziai J; Genentech, South San Francisco, CA, USA.
  • Gould SE; Genentech, South San Francisco, CA, USA.
  • Fu W; Genentech, South San Francisco, CA, USA.
  • Wang Y; Genentech, South San Francisco, CA, USA.
  • Koerber JT; Genentech, South San Francisco, CA, USA.
  • Sanjabi S; Genentech, South San Francisco, CA, USA.
  • Mellman I; Genentech, South San Francisco, CA, USA.
  • Turley SJ; Genentech, South San Francisco, CA, USA. Turley.Shannon@gene.com.
  • Müller S; Genentech, South San Francisco, CA, USA. Muller.Soren@gene.com.
Nat Commun ; 14(1): 4703, 2023 08 05.
Article in En | MEDLINE | ID: mdl-37543621
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Transforming Growth Factor beta / CD8-Positive T-Lymphocytes / B7-H1 Antigen / Immune Checkpoint Inhibitors Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Transforming Growth Factor beta / CD8-Positive T-Lymphocytes / B7-H1 Antigen / Immune Checkpoint Inhibitors Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: Country of publication: