AARDVARK: an automated reversion detector for variants affecting resistance kinetics.
Bioinformatics
; 39(8)2023 08 01.
Article
in En
| MEDLINE
| ID: mdl-37584701
ABSTRACT
SUMMARY:
Resistance to two classes of FDA-approved therapies that target DNA repair-deficient tumors is caused by mutations that restore the tumor cell's DNA repair function. Identifying these "reversion" mutations currently requires manual annotation of patient tumor sequence data. Here we present AARDVARK, an R package that automatically identifies reversion mutations from DNA sequence data. AVAILABILITY AND IMPLEMENTATION AARDVARK is implemented in R (≥3.5). It is available on GitHub at https//github.com/davidquigley/aardvark. It is licensed under the MIT license.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Software
/
DNA
Type of study:
Guideline
Limits:
Humans
Language:
En
Journal:
Bioinformatics
Journal subject:
INFORMATICA MEDICA
Year:
2023
Document type:
Article
Affiliation country: