Targeting nonalcoholic fatty liver disease via gut microbiome-centered therapies.
Gut Microbes
; 15(1): 2226922, 2023.
Article
in En
| MEDLINE
| ID: mdl-37610978
ABSTRACT
Humans possess abundant amounts of microorganisms, including bacteria, fungi, viruses, and archaea, in their gut. Patients with nonalcoholic fatty liver disease (NAFLD) exhibit alterations in their gut microbiome and an impaired gut barrier function. Preclinical studies emphasize the significance of the gut microbiome in the pathogenesis of NAFLD. In this overview, we explore how adjusting the gut microbiome could serve as an innovative therapeutic strategy for NAFLD. We provide a summary of current information on untargeted techniques such as probiotics and fecal microbiota transplantation, as well as targeted microbiome-focused therapies including engineered bacteria, prebiotics, postbiotics, and phages for the treatment of NAFLD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Probiotics
/
Microbiota
/
Non-alcoholic Fatty Liver Disease
/
Gastrointestinal Microbiome
Limits:
Humans
Language:
En
Journal:
Gut Microbes
Year:
2023
Document type:
Article
Affiliation country: