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Infiltrating CD8+ T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model.
Jorfi, Mehdi; Park, Joseph; Hall, Clare K; Lin, Chih-Chung Jerry; Chen, Meng; von Maydell, Djuna; Kruskop, Jane M; Kang, Byunghoon; Choi, Younjung; Prokopenko, Dmitry; Irimia, Daniel; Kim, Doo Yeon; Tanzi, Rudolph E.
Affiliation
  • Jorfi M; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA. mjorfi@mgh.harvard.edu.
  • Park J; Harvard Medical School, Boston, MA, USA. mjorfi@mgh.harvard.edu.
  • Hall CK; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Charlestown, MA, USA. mjorfi@mgh.harvard.edu.
  • Lin CJ; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Chen M; Harvard Medical School, Boston, MA, USA.
  • von Maydell D; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Kruskop JM; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Kang B; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Choi Y; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Prokopenko D; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Irimia D; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Kim DY; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Tanzi RE; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
Nat Neurosci ; 26(9): 1489-1504, 2023 09.
Article in En | MEDLINE | ID: mdl-37620442
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Alzheimer Disease Limits: Humans Language: En Journal: Nat Neurosci Journal subject: NEUROLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Alzheimer Disease Limits: Humans Language: En Journal: Nat Neurosci Journal subject: NEUROLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication: