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3D-printed epidermal sweat microfluidic systems with integrated microcuvettes for precise spectroscopic and fluorometric biochemical assays.
Yang, Da Som; Wu, Yixin; Kanatzidis, Evangelos E; Avila, Raudel; Zhou, Mingyu; Bai, Yun; Chen, Shulin; Sekine, Yurina; Kim, Joohee; Deng, Yujun; Guo, Hexia; Zhang, Yi; Ghaffari, Roozbeh; Huang, Yonggang; Rogers, John A.
Affiliation
  • Yang DS; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA. jrogers@northwestern.edu.
  • Wu Y; Precision Biology Research Center (PBRC), Sungkyunkwan University, Suwon, 16419, South Korea.
  • Kanatzidis EE; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA. jrogers@northwestern.edu.
  • Avila R; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Zhou M; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA. jrogers@northwestern.edu.
  • Bai Y; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
  • Chen S; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Sekine Y; Department of Mechanical Engineering, Rice University, Houston, TX, 77005, USA.
  • Kim J; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA. jrogers@northwestern.edu.
  • Deng Y; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Guo H; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA. jrogers@northwestern.edu.
  • Zhang Y; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Ghaffari R; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA. jrogers@northwestern.edu.
  • Huang Y; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Rogers JA; Materials Sciences Research Center, Japan Atomic Energy Agency, Tokai, Ibaraki 319-1195, Japan.
Mater Horiz ; 10(11): 4992-5003, 2023 10 30.
Article in En | MEDLINE | ID: mdl-37641877
Systems for capture, storage and analysis of eccrine sweat can provide insights into physiological health status, quantify losses of water, electrolytes, amino acids and/or other essential species, and identify exposures to adverse environmental species or illicit drugs. Recent advances in materials and device designs serve as the basis for skin-compatible classes of microfluidic platforms and in situ colorimetric assays for precise assessments of sweat rate, sweat loss and concentrations of wide-ranging types of biomarkers in sweat. This paper presents a set of findings that enhances the performance of these systems through the use of microfluidic networks, integrated valves and microscale optical cuvettes formed by three dimensional printing in hard/soft hybrid materials systems, for accurate spectroscopic and fluorometric assays. Field studies demonstrate the capability of these microcuvette systems to evaluate the concentrations of copper, chloride, and glucose in sweat, along with the pH of sweat, with laboratory-grade accuracy and sensitivity.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sweat / Microfluidics Type of study: Prognostic_studies Aspects: Patient_preference Language: En Journal: Mater Horiz Year: 2023 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sweat / Microfluidics Type of study: Prognostic_studies Aspects: Patient_preference Language: En Journal: Mater Horiz Year: 2023 Document type: Article Affiliation country: Country of publication: