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Lipid droplet-specific near-infrared fluorescent probe for discriminating cancer and normal cells and diagnosing fatty liver.
Zhang, Yuehua; Zhao, Han; Tang, Junshuai; Nan, Shiyu; Lu, Liqing; Zhang, Pingzhu; Wei, Chao.
Affiliation
  • Zhang Y; College of Chemistry and Materials Science, Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Hebei University, Baoding 071002, PR China.
  • Zhao H; College of Chemistry and Materials Science, Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Hebei University, Baoding 071002, PR China.
  • Tang J; College of Chemistry and Materials Science, Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Hebei University, Baoding 071002, PR China.
  • Nan S; College of Chemistry and Materials Science, Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Hebei University, Baoding 071002, PR China.
  • Lu L; Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China. Electronic address: llqxjjdcb0530@163.com.
  • Zhang P; College of Chemistry and Materials Science, Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Hebei University, Baoding 071002, PR China.
  • Wei C; College of Chemistry and Materials Science, Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Hebei University, Baoding 071002, PR China. Electronic address: weichao@hbu.edu.cn.
Bioorg Chem ; 140: 106800, 2023 11.
Article in En | MEDLINE | ID: mdl-37643567
ABSTRACT
Lipid droplets (LDs) is a newly essential organelle, which participates in carious physiological and pathological processes. LDs are considered as potential markers for disease diagnosis. Specific imaging of LDs is useful to understand their basic biological function and to diagnose diseases. Here we designed and synthesized two fluorescent probes based on the low polarity and high viscosity in LDs. The terminal probe ZH-2 exhibits lipophilicity, NIR emission, viscosity sensitivity, and LDs specificity. The probe has been successfully used for visualizing LDs metabolism, discriminating between normal and cancerous cells, and diagnosing fatty liver disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2023 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2023 Document type: Article