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FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.
Geng, Yan; Long, Xinyi; Zhang, Yuting; Wang, Yupeng; You, Guoxing; Guo, Wenjie; Zhuang, Gaoming; Zhang, Yuanyuan; Cheng, Xiao; Yuan, Zhengqiang; Zan, Jie.
Affiliation
  • Geng Y; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China.
  • Long X; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China.
  • Zhang Y; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China.
  • Wang Y; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China.
  • You G; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China.
  • Guo W; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China.
  • Zhuang G; Department of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, 511400, China.
  • Zhang Y; The affiliated TCM Hospital of Guangzhou Medical University, Guangzhou, 510130, China. gzzjzyy8034@163.com.
  • Cheng X; State Key Laboratory of Dampness, Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. chengxiaolucky@126.com.
  • Yuan Z; Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, China. chengxiaolucky@126.com.
  • Zan J; Department of Neurology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China. chengxiaolucky@126.com.
J Transl Med ; 21(1): 652, 2023 09 22.
Article in En | MEDLINE | ID: mdl-37737187
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Ataxia Telangiectasia / Exosomes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Transl Med Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Ataxia Telangiectasia / Exosomes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Transl Med Year: 2023 Document type: Article Affiliation country: Country of publication: