Regulation of cholesterol metabolism: New players for an old physiological process.
J Cell Biochem
; 124(10): 1449-1465, 2023 10.
Article
in En
| MEDLINE
| ID: mdl-37796135
ABSTRACT
Identified more than two centuries ago, cholesterol plays a pivotal role in human physiology. Since cholesterol metabolism is a physiologically significant process, it is not surprising that its alterations are associated with several pathologies. The discovery of new molecular targets or compounds able to modulate this sophisticated metabolism has been capturing the attention of research groups worldwide since many years. Endogenous and exogenous compounds are known to regulate cellular cholesterol synthesis and uptake, or reduce cholesterol absorption at the intestinal level, thereby regulating cholesterol homeostasis. However, there is a great need of new modulators and diverse new pathways have been uncovered. Here, after illustrating cholesterol metabolism and its well-known regulators, some new players of this important physiological process are also described.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cholesterol
/
Lipid Metabolism
Limits:
Humans
Language:
En
Journal:
J Cell Biochem
Year:
2023
Document type:
Article
Affiliation country: