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Gain without pain: adaptation and increased virulence of Zika virus in vertebrate host without fitness cost in mosquito vector.
Jaeger, Anna S; Marano, Jeffrey; Riemersma, Kasen K; Castaneda, David; Pritchard, Elise M; Pritchard, Julia C; Bohm, Ellie K; Baczenas, John J; O'Connor, Shelby L; Weger-Lucarelli, James; Friedrich, Thomas C; Aliota, Matthew T.
Affiliation
  • Jaeger AS; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
  • Marano J; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University , Blacksburg, Virginia, USA.
  • Riemersma KK; Department of Pathobiological Sciences, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Castaneda D; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
  • Pritchard EM; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
  • Pritchard JC; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
  • Bohm EK; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
  • Baczenas JJ; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • O'Connor SL; Wisconsin National Primate Research Center, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Weger-Lucarelli J; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Friedrich TC; Wisconsin National Primate Research Center, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Aliota MT; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University , Blacksburg, Virginia, USA.
J Virol ; 97(10): e0116223, 2023 10 31.
Article in En | MEDLINE | ID: mdl-37800949
ABSTRACT
IMPORTANCE Previously, we modeled direct transmission chains of Zika virus (ZIKV) by serially passaging ZIKV in mice and mosquitoes and found that direct mouse transmission chains selected for viruses with increased virulence in mice and the acquisition of non-synonymous amino acid substitutions. Here, we show that these same mouse-passaged viruses also maintain fitness and transmission capacity in mosquitoes. We used infectious clone-derived viruses to demonstrate that the substitution in nonstructural protein 4A contributes to increased virulence in mice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virulence / Genetic Fitness / Zika Virus / Mosquito Vectors / Culicidae Type of study: Health_economic_evaluation / Prognostic_studies Limits: Animals Language: En Journal: J Virol Year: 2023 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virulence / Genetic Fitness / Zika Virus / Mosquito Vectors / Culicidae Type of study: Health_economic_evaluation / Prognostic_studies Limits: Animals Language: En Journal: J Virol Year: 2023 Document type: Article Affiliation country: