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"Affimer" synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation.
Roper, Barnaby W R; Tiede, Christian; Abdul-Zani, Izma; Cuthbert, Gary A; Jade, Dhananjay; Al-Aufi, Ahmed; Critchley, William R; Saikia, Queen; Homer-Vanniasinkam, Shervanthi; Sawamura, Tatsuya; McPherson, Michael J; Harrison, Michael A; Tomlinson, Darren C; Ponnambalam, Sreenivasan.
Affiliation
  • Roper BWR; School of Molecular & Cellular Biology, University of Leeds, Leeds, UK.
  • Tiede C; School of Molecular & Cellular Biology, University of Leeds, Leeds, UK.
  • Abdul-Zani I; School of Molecular & Cellular Biology, University of Leeds, Leeds, UK.
  • Cuthbert GA; School of Molecular & Cellular Biology, University of Leeds, Leeds, UK; Leeds Vascular Institute, Leeds General Infirmary, Leeds, UK.
  • Jade D; School of Biomedical Sciences, University of Leeds, Leeds, UK.
  • Al-Aufi A; School of Molecular & Cellular Biology, University of Leeds, Leeds, UK; Leeds Vascular Institute, Leeds General Infirmary, Leeds, UK.
  • Critchley WR; School of Molecular & Cellular Biology, University of Leeds, Leeds, UK.
  • Saikia Q; School of Molecular & Cellular Biology, University of Leeds, Leeds, UK.
  • Homer-Vanniasinkam S; Leeds Vascular Institute, Leeds General Infirmary, Leeds, UK.
  • Sawamura T; Department of Physiology, Shinshu University, Nagano, Japan.
  • McPherson MJ; School of Molecular & Cellular Biology, University of Leeds, Leeds, UK.
  • Harrison MA; School of Biomedical Sciences, University of Leeds, Leeds, UK.
  • Tomlinson DC; School of Molecular & Cellular Biology, University of Leeds, Leeds, UK.
  • Ponnambalam S; School of Molecular & Cellular Biology, University of Leeds, Leeds, UK. Electronic address: s.ponnambalam@leeds.ac.uk.
J Biol Chem ; 299(11): 105325, 2023 11.
Article in En | MEDLINE | ID: mdl-37805141
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MAP Kinase Signaling System / Scavenger Receptors, Class E Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MAP Kinase Signaling System / Scavenger Receptors, Class E Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2023 Document type: Article Affiliation country: