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The Comparison of Machine Learning and Mechanistic In Vitro-In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance.
Keefer, Christopher E; Chang, George; Di, Li; Woody, Nathaniel A; Tess, David A; Osgood, Sarah M; Kapinos, Brendon; Racich, Jill; Carlo, Anthony A; Balesano, Amanda; Ferguson, Nicholas; Orozco, Christine; Zueva, Larisa; Luo, Lina.
Affiliation
  • Keefer CE; Translational Modeling and Simulation, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Chang G; Translational Modeling and Simulation, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Di L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Woody NA; Translational Modeling and Simulation, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Tess DA; Translational Modeling and Simulation, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.
  • Osgood SM; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Kapinos B; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Racich J; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Carlo AA; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Balesano A; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Ferguson N; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Orozco C; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Zueva L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
  • Luo L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
Mol Pharm ; 20(11): 5616-5630, 2023 11 06.
Article in En | MEDLINE | ID: mdl-37812508
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Body Fluids Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Body Fluids Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication: