Clinical benefit of transcutaneous afferent patterned stimulation (TAPS) in essential tremor patients with high unmet need: a secondary analysis of TAPS studies.
Expert Rev Med Devices
; 20(12): 1211-1218, 2023.
Article
in En
| MEDLINE
| ID: mdl-37878352
ABSTRACT
BACKGROUND:
Transcutaneous afferent patterned stimulation (TAPS) is a noninvasive neuromodulation therapy that improves hand tremor in essential tremor (ET) patients. The benefits of TAPS in ET patients with high unmet need (severe tremor, non-responsive to medication, age ≥65 years) and early responders (substantial TAPS tremor improvement in the first month) remains unknown. RESEARCH DESIGN ANDMETHODS:
Literature was surveyed for TAPS studies to assess the response in the high unmet need subgroup and early responders. Analyses were performed using previously collected Tremor Research Group Essential Tremor Rating Scale (TETRAS) scores, Bain & Findley activities of daily living (BF-ADL) scores, and tremor power.RESULTS:
Significant differences in BF-ADL and TETRAS improvement were observed with TAPS over sham for the high unmet need subgroup in a randomized controlled study (P<0.03). During a 3-month open-label study, the high unmet need subgroup and early responders showed significant improvements in BF-ADL, TETRAS, and tremor power (P<0.001). Analysis of previous real-world evidence demonstrated that early responders maintained effectiveness and usage at 3 and 12 months (P<0.001).CONCLUSIONS:
TAPS showed comparable improvements in ET with high unmet need as reported in the original studies, and greater efficacy in early responders. These findings inform patient selection and the trial process for identifying TAPS responders.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Essential Tremor
/
Deep Brain Stimulation
Limits:
Aged
/
Humans
Language:
En
Journal:
Expert Rev Med Devices
Journal subject:
DIAGNOSTICO POR IMAGEM
/
TERAPEUTICA
Year:
2023
Document type:
Article
Affiliation country: