Pd-Catalyzed Picolinamide-Directed Late-Stage Chalcogenation of Tryptophan-Containing Peptides.
J Org Chem
; 88(22): 15666-15686, 2023 11 17.
Article
in En
| MEDLINE
| ID: mdl-37883335
ABSTRACT
This report describes the Pd-catalyzed late-stage chalcogenation of tryptophan-containing peptides with disulfides/diselenides in moderate to good yields. It comprises broad substrate scope, functional group diversity, late-stage modification of drug molecules, and various valuable synthetic transformations, including room temperature easy removal of the picolinamide auxiliary, which could be applicable to tune the structure and function of peptides.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Palladium
/
Picolinic Acids
/
Tryptophan
Language:
En
Journal:
J Org Chem
Year:
2023
Document type:
Article
Affiliation country: