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Genome editing-induced t(4;11) chromosomal translocations model B cell precursor acute lymphoblastic leukemias with KMT2A-AFF1 fusion.
Pan, Feng; Sarno, Jolanda; Jeong, Johan; Yang, Xin; Jager, Astraea; Gruber, Tanja A; Davis, Kara L; Cleary, Michael L.
Affiliation
  • Pan F; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Sarno J; Department of Molecular Medicine, the University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Jeong J; Division of Pediatric Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Yang X; Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA.
  • Jager A; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Gruber TA; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Davis KL; Division of Pediatric Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Cleary ML; Stanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA.
J Clin Invest ; 134(1)2024 Jan 02.
Article in En | MEDLINE | ID: mdl-37917159
A t(4;11) leukemia model established from CRISPR-engineered chromosomal translocations between the KMT2A and AFF1 genes recapitulate proteomic, epigenomic, and transcriptomic features of primary patient leukemias.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Translocation, Genetic / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Limits: Humans Language: En Journal: J Clin Invest Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Translocation, Genetic / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Limits: Humans Language: En Journal: J Clin Invest Year: 2024 Document type: Article Affiliation country: Country of publication: