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Sex-specific associations of maternal and childhood urinary arsenic levels with emotional problems among 6-year-age children: Evidence from a longitudinal cohort study in China.
Dai, Yiming; Lu, Hanyu; Zhang, Jiming; Ding, Jiayun; Wang, Zheng; Zhang, Boya; Qi, Xiaojuan; Chang, Xiuli; Wu, Chunhua; Zhou, Zhijun.
Affiliation
  • Dai Y; Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory of Health Technology Assessment of National Health Commission, School of Public Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.
  • Lu H; Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory of Health Technology Assessment of National Health Commission, School of Public Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.
  • Zhang J; Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory of Health Technology Assessment of National Health Commission, School of Public Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China. Electronic address: zhangjiming@fudan.edu.cn.
  • Ding J; Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory of Health Technology Assessment of National Health Commission, School of Public Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.
  • Wang Z; Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory of Health Technology Assessment of National Health Commission, School of Public Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.
  • Zhang B; Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory of Health Technology Assessment of National Health Commission, School of Public Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.
  • Qi X; Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory of Health Technology Assessment of National Health Commission, School of Public Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China; Zhejiang Provincial Center for Disease Control and Prevention, No. 33
  • Chang X; Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory of Health Technology Assessment of National Health Commission, School of Public Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.
  • Wu C; Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory of Health Technology Assessment of National Health Commission, School of Public Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.
  • Zhou Z; Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory of Health Technology Assessment of National Health Commission, School of Public Health, Fudan University, No.130 Dong'an Road, Shanghai 200032, China. Electronic address: zjzhou@fudan.edu.cn.
Ecotoxicol Environ Saf ; 267: 115658, 2023 Nov 15.
Article in En | MEDLINE | ID: mdl-37925797
ABSTRACT

BACKGROUND:

Arsenic exposure has been linked to neurobehavior development disorders among children in cross-sectional studies, but there is little information on the effects of prenatal and childhood arsenic exposure on childhood behavior problem, especially emotional problems.

OBJECTIVE:

To explore the relationship between prenatal and childhood arsenic exposure and behavior problems among six-year-old children.

METHODS:

389 mother-child pairs from a longitudinal birth cohort were enrolled in the study. The concentrations of arsenic in maternal and 6-year-old children's urine were measured using inductively coupled plasma mass spectrometry (ICP-MS). Neurobehavioral development in 6-year-old children was assessed by Child Behavior Checklist (CBCL). Generalized linear regression models were used to relate arsenic exposure to the score of different domains in CBCL.

RESULTS:

The median concentrations of maternal and 6-year-old children's urinary arsenic were 22.22 and 33.86 µg/L, respectively. After adjusting for potential covariates, natural logarithm transformed concurrent urinary arsenic levels were significantly associated with scores of anxious and depressed problems in 6-year-old girls (ß = 0.71, 95% CI 0.12-1.31, p = 0.018). Furthermore, in terms of the trajectory of arsenic exposure, compared with the "consistently low" group, the "low to high" group (ß = 2.73, 95% CI -3.99 to 9.45, p = 0.425) had a greater effect on total score of CBCL than "high to low" group (ß = -0.93, 95% CI -7.22 to 5.36, p = 0.771) in girls, although insignificant.

CONCLUSIONS:

Our results suggested that concurrent arsenic exposure might have an adverse effect of emotional status in girls. Further studies are needed to verify the findings and explore the mechanisms of the sex-specific association.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arsenic Limits: Child / Female / Humans / Male / Pregnancy Country/Region as subject: Asia Language: En Journal: Ecotoxicol Environ Saf Year: 2023 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arsenic Limits: Child / Female / Humans / Male / Pregnancy Country/Region as subject: Asia Language: En Journal: Ecotoxicol Environ Saf Year: 2023 Document type: Article Affiliation country: