90Y-labeled monoclonal antibodies for cancer therapy.
Int J Rad Appl Instrum B
; 13(4): 453-6, 1986.
Article
in En
| MEDLINE
| ID: mdl-3793501
ABSTRACT
Monoclonal antibody 17-1A, which has specificity for colorectal carcinoma, was labeled with 90Y (10-20% radiolabeling yield). Tissue distribution studies in tumor-bearing nude mice were carried out. 90Y-labeled 17-1A showed good uptake in the SW 948 colon carcinoma cell line. However, 90Y-labeled A5C3, a monoclonal antihepatitis virus antibody studied as a control, showed similar uptake in this tumor. Neither antibody was taken up well by a WM-9 melanoma. It is believed that the loss of specificity observed is due to the low specific activity of the 90Y-labeled monoclonal antibody preparations used. This hypothesis is supported by radioimmunoassay data.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Yttrium Radioisotopes
/
Colonic Neoplasms
/
Antibodies, Monoclonal
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Int J Rad Appl Instrum B
Journal subject:
BIOLOGIA
/
MEDICINA NUCLEAR
Year:
1986
Document type:
Article