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Anti-inflammatory potential of some eudesmanolide and guaianolide sesquiterpenes.
Perveen, Shagufta; Hamedi, Azadeh; Pasdaran, Ardalan; Heidari, Reza; Azam, Muhammad Shafiq Ul; Tabassum, Sobia; Mehmood, Rashad; Peng, Jiangnan.
Affiliation
  • Perveen S; Department of Chemistry, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, MD, 21251, USA. shagufta792000@yahoo.com.
  • Hamedi A; Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Pasdaran A; Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Heidari R; Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. pasdaran@sums.ac.ir.
  • Azam MSU; Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. pasdaran@sums.ac.ir.
  • Tabassum S; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Mehmood R; Department of Radiology, Yeovil district hospital Somerset foundation trust (NHS), BA21 4AT,, Yeovil, Somerset, UK.
  • Peng J; Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University, Islamabad, Lahore Campus, Pakistan.
Inflammopharmacology ; 32(2): 1489-1498, 2024 Apr.
Article in En | MEDLINE | ID: mdl-37962696
ABSTRACT
Ten sesquiterpene lactones isolated from Anvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-inflammatory potential by myeloperoxidase (MPO) activity assignment, and mice paw swelling model. 3α,4α-10ß-trihydroxy-8α-acetyloxyguaian-12,6α-olide (1), epi-vulgarin (3), 9a-hydroxyparthenolide (4), garcinamine C (7), garcinamine D (8), garcinamine E (9), and 4, 9-dihydroxyguaian-10(14)-en-12-olide (10) showed explicit anti-inflammatory activity in rodent paw edema and MPO assignment. The findings of this study showed that the α-methylene γ-lactone moiety does not always guarantee an anti-inflammatory effect, but the presence of proline at the C3 of the lactone ring improves the binding of sesquiterpene lactones with MPO isoenzymes, resulting in a more potent inhibition.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Sesquiterpenes, Guaiane Limits: Animals Language: En Journal: Inflammopharmacology Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2024 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Sesquiterpenes, Guaiane Limits: Animals Language: En Journal: Inflammopharmacology Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2024 Document type: Article Affiliation country: