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Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity.
Arai, Kenta; Okumura, Masaki; Lee, Young-Ho; Katayama, Hidekazu; Mizutani, Kenji; Lin, Yuxi; Park, Sam-Yong; Sawada, Kaichiro; Toyoda, Masao; Hojo, Hironobu; Inaba, Kenji; Iwaoka, Michio.
Affiliation
  • Arai K; Department of Chemistry, School of Science, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa, 259-1292, Japan. k-arai4470@tokai-u.jp.
  • Okumura M; Institute of Advanced Biosciences, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa, 259-1292, Japan. k-arai4470@tokai-u.jp.
  • Lee YH; Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 6-3, Aramakiaza Aoba, Aoba-ku, Sendai, 980-8578, Japan.
  • Katayama H; Research Center for Bioconvergence Analysis, Korea Basic Science Institute, 162, Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, 28119, Korea.
  • Mizutani K; Bio-Analytical Science, University of Science and Technology, 217, Gajeong-ro, Yuseong-gu, Daejeon, 34113, Korea.
  • Lin Y; Graduate School of Analytical Science and Technology, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon, 34134, Korea.
  • Park SY; Research Headquarters, Korea Brain Research Institute, 61, Cheomdan-ro, Dong-gu, Daegu, 41068, Korea.
  • Sawada K; Department of Bioengineering, School of Engineering, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa, 259-1292, Japan.
  • Toyoda M; Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro, Tsurumi, Yokohama, 230-0045, Japan.
  • Hojo H; Research Center for Bioconvergence Analysis, Korea Basic Science Institute, 162, Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, 28119, Korea.
  • Inaba K; Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro, Tsurumi, Yokohama, 230-0045, Japan.
  • Iwaoka M; Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University, School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Commun Chem ; 6(1): 258, 2023 Nov 21.
Article in En | MEDLINE | ID: mdl-37989850
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Commun Chem Year: 2023 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Commun Chem Year: 2023 Document type: Article Affiliation country: Country of publication: