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Unwinding the SARS-CoV-2 Ribosomal Frameshifting Pseudoknot with LNA and G-Clamp-Modified Phosphorothioate Oligonucleotides Inhibits Viral Replication.
Knizhnik, Ekaterina; Chumakov, Stepan; Svetlova, Julia; Pavlova, Iulia; Khodarovich, Yuri; Brylev, Vladimir; Severov, Vjacheslav; Alieva, Rugiya; Kozlovskaya, Liubov; Andreev, Dmitry; Aralov, Andrey; Varizhuk, Anna.
Affiliation
  • Knizhnik E; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
  • Chumakov S; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.
  • Svetlova J; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
  • Pavlova I; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
  • Khodarovich Y; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
  • Brylev V; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.
  • Severov V; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
  • Alieva R; Research and Educational Resource Center for Cellular Technologies of The Peoples' Friendship University of Russia, 117198 Moscow, Russia.
  • Kozlovskaya L; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
  • Andreev D; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
  • Aralov A; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
  • Varizhuk A; Raman Spectroscopy Laboratory, Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia.
Biomolecules ; 13(11)2023 11 17.
Article in En | MEDLINE | ID: mdl-38002341
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Frameshifting, Ribosomal / COVID-19 Limits: Humans Language: En Journal: Biomolecules Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Frameshifting, Ribosomal / COVID-19 Limits: Humans Language: En Journal: Biomolecules Year: 2023 Document type: Article Affiliation country: