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Plasmid-mediated colistin-resistance genes: mcr.
Liu, Jian-Hua; Liu, Yi-Yun; Shen, Ying-Bo; Yang, Jun; Walsh, Timothy R; Wang, Yang; Shen, Jianzhong.
Affiliation
  • Liu JH; State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, Guangdong Provi
  • Liu YY; State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, Guangdong Provi
  • Shen YB; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
  • Yang J; State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, Guangdong Provi
  • Walsh TR; Department of Biology, University of Oxford, Oxford, UK.
  • Wang Y; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address: wangyang@cau.edu.cn.
  • Shen J; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address: sjz@cau.edu.cn.
Trends Microbiol ; 32(4): 365-378, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38008597
ABSTRACT
Colistin is regarded as a last-line drug against serious infections caused by multidrug-resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin resistance (mcr) genes has attracted global concern and led to policy changes for the use of colistin in food animals across many countries. Currently, the distribution, function, mechanism of action, transmission vehicles, origin of mcr, and new treatment strategies against MCR-producing pathogens have been extensively studied. Here we review the prevalence, structure and function of mcr, the fitness cost and persistence of mcr-carrying plasmids, the impact of MCR on host immune response, as well as the control strategies to combat mcr-mediated colistin resistance.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colistin / Escherichia coli Proteins Limits: Animals Language: En Journal: Trends Microbiol Journal subject: MICROBIOLOGIA Year: 2024 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colistin / Escherichia coli Proteins Limits: Animals Language: En Journal: Trends Microbiol Journal subject: MICROBIOLOGIA Year: 2024 Document type: Article