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Calixarene-based cryoprotectants for ice recrystallization inhibition and cell cryopreservation.
Hu, Bing; Li, Juan-Juan; Ren, Yan-Bin; Zhang, Tian-Xing; Chen, Li-Bin; Li, Xiao-Liu; Guo, Dong-Sheng; Wang, Ke-Rang.
Affiliation
  • Hu B; College of Chemistry and Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, China. k
  • Li JJ; College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China. dshguo@nankai.edu.cn.
  • Ren YB; College of Chemistry and Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, China. k
  • Zhang TX; College of Chemical Engineering, Inner Mongolia Engineering Research Center for CO2 Capture and Utilization, Key Laboratory of CO2 Resource Utilization at Universities of Inner Mongolia Autonomous Region, Inner Mongolia University of Technology, Hohhot 010051, China.
  • Chen LB; College of Chemistry and Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, China. k
  • Li XL; College of Chemistry and Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, China. k
  • Guo DS; College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China. dshguo@nankai.edu.cn.
  • Wang KR; Xinjiang Key Laboratory of Novel Functional Materials Chemistry, College of Chemistry and Environmental Sciences, Kashi University, Kashi 844000, China.
J Mater Chem B ; 11(47): 11222-11227, 2023 12 06.
Article in En | MEDLINE | ID: mdl-38013489
ABSTRACT
The development of new cryoprotectants for cryopreservation of cells has attracted considerable interest. Herein, five calixarene-based CPAs (SC4A, S-S-C4A, S-SO2-C4A, SBAC4A, and CAC4A) were developed, and their IRI activity, DIS property and cryoprotective effect were studied. SBAC4A with a sulphobetaine zwitterion and SC4A with sulfo group modification possessed better cryoprotective effects than the other calixarene-based CPAs, especially for SBAC4A with the enhanced cell viabilities of 16.16 ± 1.78%, 12.60 ± 1.15% and 14.90 ± 1.66% against MCF-7, hucMSCs and A549 cells, respectively. This result provides a supramolecular principle for developing novel CPAs with consideration of the factors of hydrogen bonding, the macromolecular crowding principle and the three-dimensional (3D) structure.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cryoprotective Agents / Calixarenes Language: En Journal: J Mater Chem B Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cryoprotective Agents / Calixarenes Language: En Journal: J Mater Chem B Year: 2023 Document type: Article