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Assessment of Cataract Risk after Diagnostic Head CT Scan Radiation Exposure in Ontario, Canada.
Emami, Pirouz; Gaudreau, Katherine; Little, Mark P; Lee, Choonsik; Moroz, Brian; Boreham, Douglas R; Thome, Christopher.
Affiliation
  • Emami P; Department of Physics & Astronomy, McMaster University, Hamilton, ON, Canada.
  • Gaudreau K; Medical Sciences Division, NOSM University, Sudbury, ON, Canada.
  • Little MP; National Cancer Institute, National Institute of Health, Bethesda, Maryland.
  • Lee C; National Cancer Institute, National Institute of Health, Bethesda, Maryland.
  • Moroz B; Computing and Software Solution for Science, LLC., Bethany Beach, Delaware.
  • Boreham DR; Medical Sciences Division, NOSM University, Sudbury, ON, Canada.
  • Thome C; School of Natural Sciences, Laurentian University, Sudbury, ON, Canada.
Radiat Res ; 201(1): 1-6, 2024 Jan 01.
Article in En | MEDLINE | ID: mdl-38014578
ABSTRACT
Ionizing radiation is one of the known risk factors for cataract development, however, there is still debate regarding the level of risk after low dose exposures. One of the largest sources of radiation exposure to the lens of the eye is diagnostic CT scans. The aim of this study was to examine whether ionizing radiation associated with head CT scans increases cataract risk in residents of Ontario, Canada. Data were collected from January 1, 1994 to December 31, 2015 (22 years) from anonymized Ontario Health Insurance Plan (OHIP) medical records for over 16 million subjects. A lens dose was estimated for each CT scan using the National Cancer Institute dosimetry system for CT (NCICT) program combined with Canada-specific CTDIvol data. Multivariate Cox proportional hazards analysis was performed with cataract extraction surgery as the primary outcome and lens dose as the main variable of interest, with inclusion of various medical and demographic covariates. Lag periods of 3, 5 and 7 years were incorporated. When lens dose was treated as a continuous variable, hazard ratios (per 100 mGy) ranged from 0.82 (0.80-0.84) to 1.10 (1.09-1.11) depending on the lag period. As a secondary analysis, when individuals were binned based on their total cumulative dose, no significant dose response pattern was observed in the low dose region. Overall, within the bounds of this study, the data do not support an increased risk of vision impairing cataracts after diagnostic head CT scan radiation exposure.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cataract / Radiation Exposure Limits: Humans Country/Region as subject: America do norte Language: En Journal: Radiat Res Year: 2024 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cataract / Radiation Exposure Limits: Humans Country/Region as subject: America do norte Language: En Journal: Radiat Res Year: 2024 Document type: Article Affiliation country: