Genomic Landscape of Pleural Mesothelioma and Therapeutic Aftermaths.
Curr Oncol Rep
; 25(12): 1515-1522, 2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-38015374
ABSTRACT
PURPOSE OF REVIEW In this article, we provide a comprehensive analysis of recent progress in the genetic characterisation of pleural mesothelioma, and the translation of these findings to clinical practice. RECENT FINDINGS:
Advancements in sequencing technology have allowed the identification of driver mutations and improved our understanding of how these mutations may shape the mesothelioma tumour microenvironment. However, the identification of frequently mutated regions including CDKN2A, BAP1 and NF2 have, to date, not yet yielded targeted therapy options that outperform standard chemo- and immunotherapies. Similarly, the association between mutational profile and the immune microenvironment or immunotherapy response is not well characterised. Further research into the link between tumour mutational profile and response to therapy is critical for identifying targetable vulnerabilities and stratifying patients for therapy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pleural Neoplasms
/
Mesothelioma, Malignant
/
Lung Neoplasms
/
Mesothelioma
Limits:
Humans
Language:
En
Journal:
Curr Oncol Rep
Journal subject:
NEOPLASIAS
Year:
2023
Document type:
Article
Affiliation country: