Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity.
Alzheimers Dement
; 20(3): 1515-1526, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38018380
ABSTRACT
INTRODUCTION:
Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 (Gal-3), a microglial activation regulator, holds promise as a therapeutic target and potential biomarker. Our study aimed to investigate Gal-3 levels in patients with FTD and assess its diagnostic potential.METHODS:
We examined Gal-3 levels in brain, serum, and cerebrospinal fluid (CSF) samples of patients with FTD and controls. Multiple linear regressions between Gal-3 levels and other FTD markers were explored.RESULTS:
Gal-3 levels were increased significantly in patients with FTD, mainly across brain tissue and CSF, compared to controls. Remarkably, Gal-3 levels were higher in cases with tau pathology than TAR-DNA Binding Protein 43 (TDP-43) pathology. Only MAPT mutation carriers displayed increased Gal-3 levels in CSF samples, which correlated with total tau and 14-3-3.DISCUSSION:
Our findings underscore the potential of Gal-3 as a diagnostic marker for FTD, particularly in MAPT cases, and highlights the relation of Gal-3 with neuronal injury markers.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Frontotemporal Dementia
Limits:
Humans
Language:
En
Journal:
Alzheimers Dement
Year:
2024
Document type:
Article
Affiliation country: