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A better understanding of the role of the CTLA-CD80/86 axis in the treatment of autoimmune diseases.
Darvish, Zahra; Kheder, Ramiar Kamal; Faraj, Tola Abdulsattar; Najmaldin, Soran K; Mollazadeh, Samaneh; Nosratabadi, Reza; Esmaeili, Seyed-Alireza.
Affiliation
  • Darvish Z; Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Kheder RK; Medical Laboratory Science Department, College of Science, University of Raparin, Rania, Sulaymaniyah, Iraq.
  • Faraj TA; Department of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, Iraq.
  • Najmaldin SK; Department of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil, Iraq.
  • Mollazadeh S; Natural Products and Medicinal Plants Research CenterÙ« North Khorasan University of Medical Sciences, Bojnurd, Iran.
  • Nosratabadi R; Department of Medical Immunology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Esmaeili SA; Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Cell Biochem Funct ; 42(1): e3895, 2024 Jan.
Article in En | MEDLINE | ID: mdl-38050849
Autoimmune diseases are diseases in which the regulatory mechanisms of the immune response are disturbed. As a result, the body loses self-tolerance. Since one of the main regulatory mechanisms of the immune response is the CTLA4-CD80/86 axis, this hypothesis suggests that autoimmune diseases potentially share a similar molecular basis of pathogenesis. Hence, investigating the CTLA4-CD80/86 axis may be helpful in finding an appropriate treatment strategy. Therefore, this study aims to investigate the molecular basis of the CTLA4-CD80/86 axis in the regulation of the immune response, and then its role in developing some autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, and multiple sclerosis. As well, the main therapeutic strategies affecting the CTLA4-CD80/86 axis have been summarized to highlight the importance of this axis in management of autoimmune diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Immunoconjugates Limits: Humans Language: En Journal: Cell Biochem Funct Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Immunoconjugates Limits: Humans Language: En Journal: Cell Biochem Funct Year: 2024 Document type: Article Affiliation country: Country of publication: