Meta-analysis of a family history of diabetes in schizophrenia.
Schizophr Res
; 264: 90-94, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38118263
ABSTRACT
OBJECTIVE:
Type 2 diabetes (T2DM) is common in patients with schizophrenia and non-affective psychosis. These patients also have an increased prevalence of a family history of T2DM. We performed a systematic review and meta-analysis of the association between a family history of T2DM and schizophrenia.METHOD:
We searched electronic databases from inception until July 2022 for studies of a family history of T2DM or gestational diabetes in patients with schizophrenia and controls. We performed random effects meta-analysis, calculating odds ratios (ORs) and 95 % confidence intervals (CI) and meta-regression analyses.RESULTS:
Nine studies were included, comprising 2953 patients with non-affective psychosis and 4484 controls. Schizophrenia was associated with an over two-fold increased odds of a family history of T2DM or gestational diabetes (OR = 2.18, 95 % CI 1.61-2.96, p < 0.01). In meta-regression analyses, age, sex, study quality score, and year of publication were all unrelated to the association.CONCLUSION:
We found that patients with schizophrenia had a 2.2-fold increased odds of a family history of T2DM versus controls. This association may be relevant to both the pathophysiology of schizophrenia and the reported increased risk of development of diabetes with antipsychotic treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Diabetes, Gestational
/
Diabetes Mellitus, Type 2
Type of study:
Systematic_reviews
Limits:
Humans
/
Pregnancy
Language:
En
Journal:
Schizophr Res
Journal subject:
PSIQUIATRIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: