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Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies.
O'Keefe, James H; Tintle, Nathan L; Harris, William S; O'Keefe, Evan L; Sala-Vila, Aleix; Attia, John; Garg, G Manohar; Hure, Alexis; Bork, Christian Sørensen; Schmidt, Erik Berg; Venø, Stine Krogh; Chien, Kuo-Liong; Chen, Yun-Yu Amelia; Egert, Sarah; Feldreich, Tobias Rudholm; Ärnlöv, Johan; Lind, Lars; Forouhi, Nita G; Geleijnse, Johanna M; Pertiwi, Kamalita; Imamura, Fumiaki; de Mello Laaksonen, Vanessa; Uusitupa, W Matti; Tuomilehto, Jaakko; Laakso, Markku; Lankinen, Maria Anneli; Laurin, Danielle; Carmichael, Pierre-Hugues; Lindsay, Joan; Leander, Karin; Laguzzi, Federica; Swenson, Brenton R; Longstreth, William T; Manson, JoAnn E; Mora, Samia; Cook, Nancy R; Marklund, Matti; Melo van Lent, Debora; Murphy, Rachel; Gudnason, Vilmundur; Ninomiya, Toshihara; Hirakawa, Yoichiro; Qian, Frank; Sun, Qi; Hu, Frank; Ardisson Korat, Andres V; Risérus, Ulf; Lázaro, Iolanda; Samieri, Cecilia; Le Goff, Mélanie.
Affiliation
  • O'Keefe JH; Saint Luke's Mid America Heart Institute, University of Missouri-Kansas City (J.H.O., E.L.O.).
  • Tintle NL; Fatty Acid Research Institute (N.L.T., W.S.H., A.S.-V., J.W.), Sioux Falls, SD.
  • Harris WS; Fatty Acid Research Institute (N.L.T., W.S.H., A.S.-V., J.W.), Sioux Falls, SD.
  • O'Keefe EL; University of South Dakota (W.S.H.), Sioux Falls, SD.
  • Sala-Vila A; Saint Luke's Mid America Heart Institute, University of Missouri-Kansas City (J.H.O., E.L.O.).
  • Attia J; Fatty Acid Research Institute (N.L.T., W.S.H., A.S.-V., J.W.), Sioux Falls, SD.
  • Garg GM; Hospital del Mar Medical Research Institute, Barcelona, Spain (A.S.-V., I.L.).
  • Hure A; The University of Newcastle, School of Biomedical Sciences and Pharmacy, Callaghan, Australia (J. Attia, G.M.G., A.H.).
  • Bork CS; The University of Newcastle, School of Biomedical Sciences and Pharmacy, Callaghan, Australia (J. Attia, G.M.G., A.H.).
  • Schmidt EB; The University of Newcastle, School of Biomedical Sciences and Pharmacy, Callaghan, Australia (J. Attia, G.M.G., A.H.).
  • Venø SK; Department of Cardiology, Aalborg University Hospital, Denmark (C.S.B.).
  • Chien KL; Department of Clinical Medicine (E.B.S.), Aalborg University Hospital, Denmark.
  • Chen YA; Department of Clinical Biochemistry (S.K.V.), Aalborg University Hospital, Denmark.
  • Egert S; National Taiwan University, Institute of Epidemiology and Preventive Medicine, Taipei (K.-L.C.).
  • Feldreich TR; Department of Medical Research, Taichung Veterans General Hospital, Taiwan (Y.-Y.C.).
  • Ärnlöv J; Institute of Nutrition and Food Sciences and Nutritional Physiology, University of Bonn, Germany (S.E.).
  • Lind L; Dalarna University, School of Health and Welfare, Falun, Sweden (T.R.F.).
  • Forouhi NG; Division of Family Medicine and Primary Care, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Solna, Sweden (J. Ärnlöv).
  • Geleijnse JM; Department of Medical Sciences Cardiovascular Epidemiology, Uppsala University, Sweden (L.L.).
  • Pertiwi K; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, United Kingdom (N.G.F., F.I.).
  • Imamura F; Division of Human Nutrition and Health, Wageningen University and Research, the Netherlands (J.M.G., K.P.).
  • de Mello Laaksonen V; Division of Human Nutrition and Health, Wageningen University and Research, the Netherlands (J.M.G., K.P.).
  • Uusitupa WM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, United Kingdom (N.G.F., F.I.).
  • Tuomilehto J; Institute of Public Health and Clinical Nutrition (V.d.M.L., W.M.U., J.T., M.A.L., J.V.), School of Medicine, University of Eastern Finland, Kuopio, Finland.
  • Laakso M; Institute of Public Health and Clinical Nutrition (V.d.M.L., W.M.U., J.T., M.A.L., J.V.), School of Medicine, University of Eastern Finland, Kuopio, Finland.
  • Lankinen MA; Institute of Public Health and Clinical Nutrition (V.d.M.L., W.M.U., J.T., M.A.L., J.V.), School of Medicine, University of Eastern Finland, Kuopio, Finland.
  • Laurin D; Department of Internal Medicine (M.L.), School of Medicine, University of Eastern Finland, Kuopio, Finland.
  • Carmichael PH; Institute of Public Health and Clinical Nutrition (V.d.M.L., W.M.U., J.T., M.A.L., J.V.), School of Medicine, University of Eastern Finland, Kuopio, Finland.
  • Lindsay J; CHU de Québec-Université Laval and VITAM Research Centers, Centre d'Excellence sur le Vieillissement de Québec, Canada (D.L., P.-H.C.).
  • Leander K; CHU de Québec-Université Laval and VITAM Research Centers, Centre d'Excellence sur le Vieillissement de Québec, Canada (D.L., P.-H.C.).
  • Laguzzi F; School of Epidemiology and Public Health, University of Ottawa, Canada (J.L.).
  • Swenson BR; Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular and Nutritional Epidemiology, Stockholm, Sweden (K.L., F.L.).
  • Longstreth WT; Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular and Nutritional Epidemiology, Stockholm, Sweden (K.L., F.L.).
  • Manson JE; Cardiovascular Health Research Unit (B.R.S.), University of Washington, Seattle.
  • Mora S; Departments of Neurology and Epidemiology (W.T.L.), University of Washington, Seattle.
  • Cook NR; Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA (J.E.M., S.M., N.R.C.).
  • Marklund M; Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA (J.E.M., S.M., N.R.C.).
  • Melo van Lent D; Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA (J.E.M., S.M., N.R.C.).
  • Murphy R; The George Institute for Global Health, University of New South Wales, Newtown, Australia (M.M.).
  • Gudnason V; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.M.).
  • Ninomiya T; Department of Public Health and Caring Sciences, Uppsala University, Sweden (M.M.).
  • Hirakawa Y; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas, San Antonio (D.M.v.L.).
  • Qian F; Cancer Control Research, British Columbia Cancer, School of Population and Public Health, University of British Columbia, Vancouver, Canada (R.M.).
  • Sun Q; Icelandic Heart Institute, Kopavogur, Iceland (V.G.).
  • Hu F; Department of Epidemiology and Public Health and Center for Cohort Studies, Kyushu University, Fukouka, Japan (T.N., Y.H.).
  • Ardisson Korat AV; Department of Epidemiology and Public Health and Center for Cohort Studies, Kyushu University, Fukouka, Japan (T.N., Y.H.).
  • Risérus U; Harvard Medical School, T.H. Chan School of Public Health and Beth Deaconess Medical Center, Boston, MA (F.Q.).
  • Lázaro I; Harvard Medical School, T.H. Chan School of Public Health and Channing Division of Network Medicine Brigham and Women's Hospital, Boston, MA (Q.S., F.H.).
  • Samieri C; Harvard Medical School, T.H. Chan School of Public Health and Channing Division of Network Medicine Brigham and Women's Hospital, Boston, MA (Q.S., F.H.).
  • Le Goff M; USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA (A.V.A.K.).
Stroke ; 55(1): 50-58, 2024 01.
Article in En | MEDLINE | ID: mdl-38134264
ABSTRACT

BACKGROUND:

The effect of marine omega-3 PUFAs on risk of stroke remains unclear.

METHODS:

We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome.

RESULTS:

Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.

CONCLUSIONS:

Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fatty Acids, Omega-3 / Stroke / Ischemic Stroke / Hemorrhagic Stroke Limits: Humans Language: En Journal: Stroke Year: 2024 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fatty Acids, Omega-3 / Stroke / Ischemic Stroke / Hemorrhagic Stroke Limits: Humans Language: En Journal: Stroke Year: 2024 Document type: Article