Ketone bodies as chemical signals for the immune system.
Am J Physiol Cell Physiol
; 326(3): C707-C711, 2024 03 01.
Article
in En
| MEDLINE
| ID: mdl-38189135
ABSTRACT
Ketone bodies are short-chain fatty acids produced by the liver during periods of limited glucose availability, such as during fasting or low carbohydrate feeding. Recent studies have highlighted important nonmetabolic functions of the most abundant ketone body, ß-hydroxybutyrate (BHB). Notably, many of these functions, including limiting specific sources of inflammation, histone deacetylase inhibition, NFκB inhibition, and GPCR stimulation, are particularly important to consider in immune cells. Likewise, dietary manipulations like caloric restriction or ketogenic diet feeding have been associated with lowered inflammation, improved health outcomes, and improved host defense against infection. However, the underlying mechanisms of the broad benefits of ketosis remain incompletely understood. In this Perspective, we contextualize the current state of the field of nonmetabolic functions of ketone bodies specifically in the immune system and speculate on the molecular explanations and broader physiological significance.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ketone Bodies
/
Ketosis
Limits:
Humans
Language:
En
Journal:
Am J Physiol Cell Physiol
/
Am. j. physiol. cell physiol
/
American journal of physiology. Cell physiology
Journal subject:
FISIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: