Studying serum neurofilament light chain levels as a potential new biomarker for small fiber neuropathy.
Eur J Neurol
; 31(4): e16192, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38189534
ABSTRACT
BACKGROUND AND PURPOSE:
Diagnosing small fiber neuropathies can be challenging. To address this issue, whether serum neurofilament light chain (sNfL) could serve as a potential biomarker of damage to epidermal Aδ- and C-fibers was tested.METHODS:
Serum NfL levels were assessed in 30 patients diagnosed with small fiber neuropathy and were compared to a control group of 19 healthy individuals. Electrophysiological studies, quantitative sensory testing and quantification of intraepidermal nerve fiber density after skin biopsy were performed in both the proximal and distal leg.RESULTS:
Serum NfL levels were not increased in patients with small fiber neuropathy compared to healthy controls (9.1 ± 3.9 and 9.4 ± 3.8, p = 0.83) and did not correlate with intraepidermal nerve fiber density at the lateral calf or lateral thigh or with other parameters of small fiber impairment.CONCLUSION:
Serum NfL levels cannot serve as a biomarker for small fiber damage.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peripheral Nervous System Diseases
/
Small Fiber Neuropathy
Limits:
Humans
Language:
En
Journal:
Eur J Neurol
Journal subject:
NEUROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: