Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
Medicine (Baltimore)
; 102(52): e36759, 2023 Dec 29.
Article
in En
| MEDLINE
| ID: mdl-38206745
ABSTRACT
BACKGROUND:
Hashimoto's thyroiditis (HT) is the prevailing form of autoimmune thyroiditis and the leading cause of hypothyroidism in iodine-sufficient regions worldwide. This study aims to evaluate the efficacy of vitamin D supplementation on HT through a meta-analysis of randomized controlled trials (RCTs).METHODS:
The databases searched included PubMed, and others. We included RCTs that the treatment group received vitamin D, while the control group received either a placebo or no treatment. The studies measured the baseline and endpoint levels of 25-hydroxyvitamin D [25(OH)D], thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), anti-thyroid peroxidase antibody (TPO-Ab), and thyroglobulin antibody (TG-Ab). We performed a meta-analysis to calculate the standardized mean difference (SMD) and 95% confidence interval (CI).RESULTS:
A total of 12 studies involving 862 individuals were included. Vitamin D supplementation has a significant impact on reducing the titers of TPO-Ab (SMDâ =â -1.084, 95% CIâ =â -1.624 to -0.545) and TG-Ab (SMDâ =â -0.996, 95% CIâ =â -1.579 to -0.413) in patients with HT, and it also improves thyroid function by decreasing TSH level (SMDâ =â -0.167, 95% CIâ =â -0.302 to 0.031) and increasing FT3 (SMDâ =â 0.549, 95% CIâ =â 0.077-1.020) and FT4 (SMDâ =â 0.734, 95% CIâ =â 0.184-1.285) levels. Active vitamin D (calcitriol) significantly reduces the titer of TPO-Ab compared to naive forms of vitamin D (vitamin D2 or D3); treatment durationsâ >â 12 weeks result in a more effective reduction of TPO-Ab levels and a more significant increase in FT4 and FT3 levels in patients with HT (meta-regression Pâ <â .05).CONCLUSION:
Vitamin D supplementation may have beneficial effects on HT patients by modulating immune responses and improving thyroid function.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin D
/
Hashimoto Disease
Type of study:
Clinical_trials
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Medicine (Baltimore)
Year:
2023
Document type:
Article
Affiliation country:
Country of publication: